The AnteAGE® MD SERUM

The AnteAGE®MD Serum

AnteAGE® MD contains twice the Stem Cytokines™ found in AnteAGE®, along with additional ingredients to provide enhanced anti-aging, pro-healing and anti-inflammatory benefits. With daily use it improves the health and appearance of skin, no matter what one’s age, and is particularly well suited for use as a topical adjuvant to promote healing and reduce inflammation following medical esthetic procedures.

The stem cell technology behind AnteAGE® MD is cutting edge and published in multiple peer-reviewed medical journals. Combining it with more than a dozen additional scientifically proven actives makes AnteAGE MD uniquely effective and the most complete skincare system available.

Its powerful ingredients also make it the perfect post-procedure topical adjuvant following laser, microneedling, abrasive, and other ablative or collagen inducting medical esthetic treatments.

ANY SKIN TYPE

A.M. & P.M. Apply 2-3 pumps onto clean skin.

Ingredients

 

There is a lot of amazing science and years of experience in the AnteAGE® Serum.

To learn the definition, physiology, and published literature documenting the benefit of each active Serum ingredient, click on the appropritate tab below


Mesenchymal Stem Cytokines

Definition: Mesenchymal stem cytokines are biochemical molecular signals produced by mesenchymal stem cells that affect other cells, in effect functioning as “command and control” over the processes of healing and inflammation.

Physiology: Mesenchymal stem cells migrate from the bone marrow to sites of injury in response to chemical “S.O.S.” signals called chemokines that are released by injured tissue. Once there, they secrete cytokines which modulate and control inflammation and healing through multiple actions on a variety of cells including local stem cells, other tissue cells, and white cells from the blood. Mesenchymal stem calls can also transform into specific types of cells needed to repair skin, bone, cartilage, muscle, and other tissues.

References:

1. Cytokines as the major mechanism of Mesenchymal stem cell clinical activity: expanding the spectrum of cell therapy. Journal of the Israel Medical Association, April 2011

2. Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. Journal of Cell Physiology. Nov 2007

3. Mesenchymal stem cell-conditioned medium accelerates skin wound healing: an in vitro study of fibroblast and keratinocyte scratch assay. Experimental Cellular Research. April 2010

4. Paracrine Factors of Mesenchymal Stem Cells Recruit Macrophages and Endothelial Lineage Cells and Enhance Wound Healing; PLoS ONE, April 2008

Niacinamide (Vit B3)

Definition: Niacinamide is also known as vitamin B3 and is essential in the diet.

Physiology: The topical benefits of Niacinamide are improved skin moisturization, softness and suppleness. It is known that several lipids such as fatty acids and ceramides are critical for the structural and functional integrity of the stratum corneum, the horny surface layer of the skin that serves as barrier to water loss from deeper layers. Niacinamide is shown to reduce transdermal water loss and boost free fatty acids and ceramindes. Niacinamide increases keratin and other epidermal proteins, fibroblasts, and collagen secretion.

References:

1. Niacinamide: A B Vitamin that Improves Aging Facial Skin Appearance. Dermatologic Surgery, March 2006

2. Topical niacinamide provides skin aging appearance benefits while enhancing barrier function. Textbook of Cosmetic Dermatology Nicotinic acid/niacinamide and the skin. Journal of Cosmetic Dermatology. Nov. 2004

Carnosine

Definition: Carnosine is a dipeptide of the amino acids beta-alanine and histidine.

Physiology: Proteins are endangered by a damaging process known as glycation, a non-enzymatic reaction between proteins and sugars. Glycation irreversibly alters the configuration of proteins, creating Advanced Glycation End-Products or AGEs. AGEs have been implicated in many of the diseases associated with aging. Carnosine helps defend proteins against glycation. Carnosine is also a powerful antioxidant.

References:

1. Efficacy of anti-aging products for periorbital wrinkles as measured by 3-D imaging. Journal Cosmetic Dermatology. Sept 2009

2. Action of carnosine and beta-alanine on wound healing. Surgery. Nov1986 Carnosine, histidine, and wound healing. Surgery, 1982 – ncbi.nlm.nih.gov

Palmitoyl oligopeptide

Definition: Palmitoyl oligopeptide is a chain of five amino acids bonded together and linked to a fatty acid. It consists of the amino acids glycine, glutamine, proline and arginine.

Physiology: Palmitoyl oligopeptide stimulates the synthesis of collagen and hyaluronic acid in the deep layers of the skin. It also provides mild UV protection that helps protect the skin from sun damage. It was developed as the result of research to duplicate the effects of retinoic acid (retinol) without skin irritation.

References:

1. Cosmeceutical peptides. Dermatologic Therapy. Nov 2007 Cosmeceuticals and peptides.

2. Clinics in Dermatology, Sept-Oct 2009

3. Bioactive peptides: signaling the future. Journal of Cosmetic Dermatology. March 2009

Palmitoyl tetrapeptide-7

Definition: A synthetic peptide complex that acts as a cellular messenger to stimulate collagen and Hyaluronic Acid to increase skin elasticity and tone.

Physiology: Messenger molecules that repair and activate the neosynthesis of the extracellular matrix and increase cell proliferation. Improves the visible appearance of wrinkles.

References:

1. Cosmeceutical peptides. Dermatologic Therapy. Nov2007 Cosmeceuticals and peptides. Clinics in Dermatology, Sept-Oct 2009
2. Bioactive peptides: signaling the future. Journal of Cosmetic Dermatology. Mar 2009

Catechins & flavonoids

Definition: The term catechins is also commonly used to refer to the related family of flavonoids and the subgroup flavan-3-ols (or simply flavanols). The catechins/flavanoids in the serum include:

• Camelia Sinensus (green tea)
• Myrtus Communis (myrtle)
• Ilex paraguariensis (organic yerba mate)

Physiology: Messenger molecules that repair and activate the neosynthesis of the extracellular matrix and increase cell proliferation. Improves the visible appearance of wrinkles.

References:

1. Antioxidant activity of flavonoids: Efficiency of singlet oxygen quenching. Journal of Photochemistry and Photobiology, August 1993
2. Flavonoids: Chemistry, Biochemistry and Applications. CRC Press. (2006).